بررسی اثرات ضد دردی گیاه کاکوتی (Ziziphora tenuior L.) در موش کوچک آزمایشگاهی نر بالغ

Background : Ziziphora tenuior is one of the traditional medicinal plants. The main active chemical compounds in this plant is Pulegone that its anti-inflammatory and its analgesic effects is well specified. In the present study, the analgesic effects of Ziziphora tenuior native of Sirjan zone (underflow) on the adult male mice was studied. Materials and Methods: In this study, after collecting leaf and twigs in Sirjan zone, The extract of Ziziphora tenuior was prepared by soaking method. Action of analgesia was evaluated using the formalin test. Hydro alcoholic extract at concentrations of 50, 100 and 150 mg per kg of body weight, was injected intraperitoneally. The control group had no treatment, and case group received drug solvent, normal saline intraperitoneally, and group 6 received morphine to rate of 0/2 mg kg. The data gathered and analyzed by SPSS 17 software and ANOVA statistical test in a significant level (P<0/05). Results: The results of this study showed that in adult male rats intraperitoneal injection of Ziziphora tenuior of Pariz zone (Sirjan) at concentrations of 50, 100 and 150 mg kg as morphine reduced the primary and secondary phases of pain which induced by formalin . Conclusion: The data showed that the medicinal herb of Ziziphora tenuior, has analgesic effects on mice and this plant should be considered in future treatments and it can be a good alternative to chemical drugs.